The effects of antifungal agents on the morphogenetic transformation by Candida albicans in vitro | Zendy

Stephen Hawser | Zendy; Maura Francolini | Zendy; Khalid Islam | Zendy

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The effects of antifungal agents on the morphogenetic transformation by Candida albicans in vitro

Author(s) -

Stephen Hawser,

Maura Francolini,

Khalid Islam

Publication year - 1996

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/38.4.579

Subject(s) - candida albicans , amphotericin b , transformation (genetics) , microbiology and biotechnology , in vitro , corpus albicans , biology , chemistry , antifungal , biochemistry , gene

The effects of antifungal agents, with different mechanisms of action, on the morphogenetic transformation by synchronised yeast-phase Candida albicans cells in vitro and their respective anti-Candida activities are described. MIC data demonstrated that the azoles, amphotericin B and echinocandin were the most active agents against four C. albicans strains. Morphogenetic transformation experiments demonstrated that amphotericin B was significantly better at preventing the transformation, under a variety of test conditions, than the azoles and flucytosine: amphotericin B abolished the transformation at low concentrations while the azoles only prevented the morphogenetic transformation at much higher concentrations (> 100 x MIC).

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