Comparative activity of azithromycin against clinical isolates of mycobacteria | Zendy

B. Watt | Zendy; A. Rayner | Zendy; G. Harris | Zendy

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Comparative activity of azithromycin against clinical isolates of mycobacteria

Author(s) -

B. Watt,

A. Rayner,

G. Harris

Publication year - 1996

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/38.3.539

Subject(s) - azithromycin , microbiology and biotechnology , mycobacterium marinum , mycobacterium , mycobacterium tuberculosis , tuberculosis , mycobacterium avium complex , biology , mycobacterium avium intracellulare infection , medicine , antibiotics , virology , pathology

Azithromycin exhibited in-vitro activity against 20 clinical isolates of Mycobacterium avium complex for which the MIC90 was 32 mg/L and 22 clinical isolates of other mycobacteria but showed no activity against 20 isolates of Mycobacterium tuberculosis (MIC90 > 128 mg/L) nor against the single isolate of Mycobacterium marinum tested (MIC 128 mg/L). These results suggest that the drug may prove useful for the prophylaxis and treatment of infections due to non-tuberculous mycobacteria, including M. avium complex in patients with AIDS.

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