Open AccessEffect of ciprofloxacin on ciliary motility of rabbit airway epithelium
Author(s) -
H Takemura,
Jun Tamaoki,
Atsushi Chiyotani,
Kimio Konno
Publication year - 1996
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/38.1.139
Subject(s) - motility , verapamil , propranolol , respiratory epithelium , airway , epithelium , ciprofloxacin , lagomorpha , biology , chemistry , pharmacology , endocrinology , medicine , respiratory system , anatomy , anesthesia , microbiology and biotechnology , pathology , antibiotics , calcium
To determine the effect of the new quinolone ciprofloxacin on airway ciliary motility, we studied ciliary beat frequency (CBF) of rabbit tracheal epithelium using an in-vitro microphoto-oscillation method. Incubation of the cells with ciprofloxacin increased CBF in a concentration-dependent manner, the maximal increase from the baseline value and the EC50 being 17.1 +/- 2.0% (P < 0.01) and 10(-7.25) M, respectively. This ciliary stimulatory effect was not affected by propranolol or indomethacin but was nullified by verapamil. These results suggest that ciprofloxacin probably increases airway epithelial ciliary motility by facilitating Ca2+ influx through a voltage-dependent channel.
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