Effect of growth conditions on antimicrobial activity of DU-6859a and its bactericidal activity determined by the killing curve method | Zendy

Mayumi Tanaka | Zendy; Kazuki Hoshino | Zendy; Masato Hohmura | Zendy; Hiroko Ishida | Zendy; Akihiro Kitamura | Zendy; Kenichi Sato | Zendy; I Hayakawa | Zendy; Takeshi Nishino | Zendy

Open Access

Effect of growth conditions on antimicrobial activity of DU-6859a and its bactericidal activity determined by the killing curve method

Author(s) -

Mayumi Tanaka,

Kazuki Hoshino,

Masato Hohmura,

Hiroko Ishida,

Akihiro Kitamura,

Kenichi Sato,

I Hayakawa,

Takeshi Nishino

Publication year - 1996

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/37.6.1091

Subject(s) - sparfloxacin , microbiology and biotechnology , ciprofloxacin , pseudomonas aeruginosa , staphylococcus aureus , streptococcus pneumoniae , antimicrobial , escherichia coli , antibacterial activity , bacteria , chemistry , antibacterial agent , minimum bactericidal concentration , antibiotics , levofloxacin , ofloxacin , biology , minimum inhibitory concentration , biochemistry , genetics , gene

The effect of growth conditions on the antibacterial activity of DU-6859a against Staphylococcus auerus, Escherichia coli, and Pseudomonas aeruginosa was compared with those of levofloxacin, sparfloxacin, and ciprofloxacin. This activity was not affected by different media, inoculum size or the addition of human serum, but was decreased under acidic conditions, in human urine, and in the presence of magnesium and ferrous ion, as were the other quinolones tested. Time-kill curve studies demonstrated the bactericidal action of DU-6859a against S. aureus, Streptococcus pneumoniae, E. coli, and P. aeruginosa. Morphological alteration of these bacteria after exposure to DU-6859a also demonstrated its bactericidal activity. The frequency of spontaneous resistance to DU-6859a was less than or equal to those of the reference drugs.

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