The effect of rifampicin on adaptive resistance of Pseudomonas aeruginosa to aminoglycosides | Zendy

Yan-Qiong Xiong | Zendy; J. Caillon | Zendy; H. Drugeon | Zendy; G. Potel | Zendy; Denis Baron | Zendy

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The effect of rifampicin on adaptive resistance of Pseudomonas aeruginosa to aminoglycosides

Author(s) -

Yan-Qiong Xiong,

J. Caillon,

H. Drugeon,

G. Potel,

Denis Baron

Publication year - 1996

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/37.5.993

Subject(s) - netilmicin , amikacin , rifampicin , aminoglycoside , pseudomonas aeruginosa , microbiology and biotechnology , antibacterial agent , medicine , antibiotics , gentamicin , biology , tobramycin , bacteria , genetics

Using the dynamic chequerboard technique, we confirmed that rifampicin produces a synergistic bactericidal effect when combined with amikacin or netilmicin. Adaptive resistance was suppressed when rifampicin was added to aminoglycoside after, but not during, first exposure to amikacin or netilmicin. The effect of rifampicin on adaptive resistance could account for the synergy between rifampicin and aminoglycosides.

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