In-vitro activity of psychiatric drugs against Corynebacterium urealyticum (Corynebacterium group D2) | Zendy

J. L. Muñioz-Bellido | Zendy; S. Muñioz-Bellido | Zendy; J. A. García-Rodrfguez | Zendy

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In-vitro activity of psychiatric drugs against Corynebacterium urealyticum (Corynebacterium group D2)

Author(s) -

J. L. Muñioz-Bellido,

S. Muñioz-Bellido,

J. A. García-Rodrfguez

Publication year - 1996

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/37.5.1005

Subject(s) - ciprofloxacin , microbiology and biotechnology , tetracycline , clindamycin , cefotaxime , antibacterial agent , teicoplanin , sertraline , trimethoprim , pharmacology , medicine , antibiotics , vancomycin , biology , bacteria , staphylococcus aureus , antidepressant , genetics , hippocampus

We tested the in-vitro activity of amoxycillin, amoxycillin/clavulanic acid, cefotaxime, gentamicin, trimethoprim-sulphamethoxazole, tetracycline, norfloxacin, ciprofloxacin, vancomycin, teicoplanin, clindamycin and five psychiatric drugs (chlorpromazine, sertraline, fluoxetine, paroxetine and risperidone) against 32 strains of Corynebacterium urealyticum. Resistance rates exceeded 90% for all antibiotics except glycopeptides, quinolones and tetracycline. Sertraline was the most active psychiatric drug. We tested the influence of sertraline on the activity of amoxycillin, amoxycillin/clavulanic acid, cefotaxime, gentamicin, trimethoprim-sulphamethoxazole, tetracycline and ciprofloxacin. We did not observe antagonism in any case. Sertraline enhanced the activity of ciprofloxacin and tetracycline against all strains (MIC decrease: 4-64-fold for ciprofloxacin, 2-32-fold for tetracycline).

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