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The susceptibility of Neisseria gonorrhoeae to PD 131628 and grepafloxacin (OPC 17116) was evaluated by agar dilution and disc diffusion methods. A tentative susceptibility category for both fluoroquinolones included strains for which the MICs are &lt; or = 0.06 mg/L and the zones of inhibition are &gt; or = 38 mm for PD 131628 and &gt; or = 37 mm for grepafloxacin. Quality control studies with N. gonorrhoeae ATCC 49226 suggested that agar dilution MIC limits were 0.002-0.008 mg/L and 0.004-0.03 mg/L for PD 131628 and grepafloxacin, respectively. The zone size limits were 50-58 mm for PD 131628 and 44-52 mm for grepafloxacin.

the journal of antimicrobial chemotherapy/journal of antimicrobial chemotherapy

Tentative interpretive criteria and quality control parameters for in-vitro susceptibility testing of <i>Neisseria gonorrhoeae</i> to two fluoroquinolones (PD 131628 and grepafloxacin (OPC 17116))

Tentative interpretive criteria and quality control parameters for in-vitro susceptibility testing of Neisseria gonorrhoeae to two fluoroquinolones (PD 131628 and grepafloxacin (OPC 17116))