A pro-inflammatory role of Fcα/μR on marginal zone B cells in sepsis | Zendy

Akira Shibuya | Zendy; Shinichiro Honda | Zendy; Kazuko Shibuya | Zendy

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A pro-inflammatory role of Fcα/μR on marginal zone B cells in sepsis

Author(s) -

Akira Shibuya,

Shinichiro Honda,

Kazuko Shibuya

Publication year - 2017

Publication title -

international immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.86

H-Index - 134

eISSN - 1460-2377

pISSN - 0953-8178

DOI - 10.1093/intimm/dxx059

Subject(s) - receptor , fc receptor , fragment crystallizable region , immunology , sepsis , marginal zone , antibody , immune system , biology , microbiology and biotechnology , chemistry , b cell , biochemistry

Fc receptors play important roles for a wide array of immune responses. In contrast to the well-defined Fcγ and Fcε receptors, the molecular and functional characteristics of Fc receptors for IgA and IgM have remained incompletely understood for years. Recent progress has unveiled the characteristics of Fc receptors for IgA and IgM, including Fcα/μ receptor (Fcα/μR) (CD351), polymeric immunoglobulin receptor (poly-IgR), Fcα receptor (FcαRI) (CD89) and Fcμ receptor (FcμR). In this review, we summarize the molecular and functional characteristics of Fcα/μR in comparison with poly-IgR, FcμR and FcαRI, and focus particularly on the pro-inflammatory function of Fcα/μR expressed on marginal zone B cells in sepsis.

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