Chemical modifications on siRNAs avoid Toll-like-receptor-mediated activation of the hepatic immune system in vivo and in vitro | Zendy

Ruth Broering | Zendy; C.I. Real | Zendy; Matthias John | Zendy; Kerstin JahnHofmann | Zendy; Ludger M. Ickenstein | Zendy; K Kleinehr | Zendy; Andreas Paul | Zendy; Kathrin Gibbert | Zendy; Ulf Dittmer | Zendy; Guido Gerken | Zendy; JF Schlaak | Zendy

Open Access

Chemical modifications on siRNAs avoid Toll-like-receptor-mediated activation of the hepatic immune system in vivo and in vitro

Author(s) -

Ruth Broering,

C.I. Real,

Matthias John,

Kerstin JahnHofmann,

Ludger M. Ickenstein,

K Kleinehr,

Andreas Paul,

Kathrin Gibbert,

Ulf Dittmer,

Guido Gerken,

JF Schlaak

Publication year - 2013

Publication title -

international immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.86

H-Index - 134

eISSN - 1460-2377

pISSN - 0953-8178

DOI - 10.1093/intimm/dxt040

Subject(s) - small interfering rna , in vivo , rna interference , in vitro , immune system , transfection , biology , microbiology and biotechnology , chemistry , cell culture , immunology , rna , biochemistry , gene , genetics

The therapeutic application of small interfering RNAs (siRNAs) is limited by the induction of severe off-target effects, especially in the liver. Therefore, we assessed the potential of differently modified siRNAs to induce the hepatic innate immune system in vitro and in vivo.

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