Danger-associated metabolic modifications during bacterial infection of macrophages | Zendy

Mariatou Dramé | Zendy; Carmen Buchrieser | Zendy; Pedro Escoll | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Danger-associated metabolic modifications during bacterial infection of macrophages

Author(s) -

Mariatou Dramé,

Carmen Buchrieser,

Pedro Escoll

Publication year - 2020

Publication title -

international immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.86

H-Index - 134

eISSN - 1460-2377

pISSN - 0953-8178

DOI - 10.1093/intimm/dxaa035

Subject(s) - bacteria , intracellular , immune system , inflammasome , macrophage , intracellular parasite , metabolism , biology , microbiology and biotechnology , function (biology) , cell metabolism , cellular metabolism , microbial metabolism , metabolic pathway , metabolic activity , inflammation , immunology , biochemistry , physiology , genetics , in vitro

In this review, we propose that certain modifications in cellular metabolism might function as danger signals triggering inflammasome-mediated immune responses. We propose to call them danger-associated metabolic modifications (DAMMs). As intracellular bacteria can actively modulate macrophage metabolism for their benefit, infected host cells might sense bacteria-induced metabolic alterations and activate immune reactions. Here we report the known metabolic interactions that occur during infection of macrophages by intracellular bacteria and discuss the possible emergence of DAMMs upon bacteria-induced alterations of cellular metabolism.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research