Open AccessCD4 and CD8 expressions in African green monkey helper T lymphocytes: implication for resistance to SIV infection
Author(s) -
Yuichi Murayama,
Akira Amano,
R Mukai,
Hiroshi Shibata,
S. Matsunaga,
Hikaru Takahashi,
Yoshie Yoshikawa,
Masanori Hayami,
Atsushi Noguchi
Publication year - 1997
Publication title -
international immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.86
H-Index - 134
eISSN - 1460-2377
pISSN - 0953-8178
DOI - 10.1093/intimm/9.6.843
Subject(s) - simian immunodeficiency virus , cd8 , virology , biology , cytotoxic t cell , panning (audio) , t lymphocyte , microbiology and biotechnology , immunology , phenotype , virus , antigen , in vitro , gene , genetics , paleontology , zoom , lens (geology)
We found that most peripheral CD4 cells co-express a low density of CD8 alpha antigen in African green monkeys (AGM). Further, the cell surface expression of CD4 and the expression of CD4 mRNA underwent a decrease when purified CD4CD8low cells were cultured with mitogen and IL-2. These observations suggest that AGM CD4 cells are subject to loss of CD4 expression after lymphocyte activation. Part of the peripheral CD8 fraction exhibited a significant helper activity which suggested the phenotypic conversion in helper T cells from CD4+ to CD4- in vivo. Simian immunodeficiency virus (SIV) grew well in CD4 panning cells following SIV infection. In contrast, CD4CD8low cells were resistant to SIV infection after their conversion to CD4- cells.
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