The appearance of Thy-1− donor T cells in the peripheral circulation 3–6 weeks after bone marrow transplantation suggests an extrathymic origin | Zendy

Ruikun Zhong | Zendy; Albert D. Donnenberg | Zendy; Linette J. Edison | Zendy; David E. Harrison | Zendy

Open Access

The appearance of Thy-1⁻ donor T cells in the peripheral circulation 3–6 weeks after bone marrow transplantation suggests an extrathymic origin

Author(s) -

Ruikun Zhong,

Albert D. Donnenberg,

Linette J. Edison,

David E. Harrison

Publication year - 1996

Publication title -

international immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.86

H-Index - 134

eISSN - 1460-2377

pISSN - 0953-8178

DOI - 10.1093/intimm/8.2.171

Subject(s) - bone marrow , spleen , transplantation , population , isotype , cd8 , immunology , congenic , microbiology and biotechnology , antigen , pathology , biology , antibody , medicine , monoclonal antibody , environmental health , biochemistry , gene

Donor and host T cells were distinguished by T cell antigen marker Thy-1 isotype and cytoplasmic isozyme Gpi-1 in this study of bone marrow transplantation between congenic mice. During the first 3-6 weeks after irradiation and marrow transfer, percentages of cells bearing the donor Thy-1 isotype in the periphery are much lower than percentages of T cells bearing the donor Gpi-1 marker. Apparently a population of Thy-1- donor T cells exists for several weeks after bone marrow transplantation. Further study showed that this population of CD3+, Thy-1- donor T cells expressed CD4+ or CD8+ and was found in peripheral blood and spleen but not in the thymus. This finding suggests their extrathymic origin.

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