Non-coding plasmid DNA induces IFN-γ in vivo and suppresses autoimmune encephalomyelitis | Zendy

Graciela L. Boccaccio | Zendy; Felix Mor | Zendy; Lawrence Steinman | Zendy

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Non-coding plasmid DNA induces IFN-γ in vivo and suppresses autoimmune encephalomyelitis

Author(s) -

Graciela L. Boccaccio,

Felix Mor,

Lawrence Steinman

Publication year - 1999

Publication title -

international immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.86

H-Index - 134

eISSN - 1460-2377

pISSN - 0953-8178

DOI - 10.1093/intimm/11.2.289

Subject(s) - experimental autoimmune encephalomyelitis , plasmid , dna vaccination , autoimmune disease , naked dna , in vivo , autoimmunity , dna , cytokine , encephalomyelitis , immunology , recombinant dna , biology , gene , immune system , antibody , genetics , multiple sclerosis

Regulatory sequences used in plasmids for naked DNA vaccination can modulate cytokine production in vivo. We demonstrate here that injection of plasmid DNA can suppress the prototypic T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis, by inducing IFN-gamma.

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