Pneumococcal Colonization in Healthy Adult Research Participants in the Conjugate Vaccine Era, United Kingdom, 2010–2017 | Zendy

Hugh Adler | Zendy; Elissavet Nikolaou | Zendy; Katherine A. Gould | Zendy; Jason Hinds | Zendy; Andrea M. Collins | Zendy; Victoria Connor | Zendy; Caz Hales | Zendy; Helen Hill | Zendy; Angela Hyder-Wright | Zendy; Seher Zaidi | Zendy; Esther L. German | Zendy; Jenna F. Gritzfeld | Zendy; Elena Mitsi | Zendy; Sherin Pojar | Zendy; Stephen B. Gordon | Zendy; Adam P. Roberts | Zendy; Jamie Rylance | Zendy; Daniela M. Ferreira | Zendy

Open Access

Pneumococcal Colonization in Healthy Adult Research Participants in the Conjugate Vaccine Era, United Kingdom, 2010–2017

Author(s) -

Hugh Adler,

Elissavet Nikolaou,

Katherine A. Gould,

Jason Hinds,

Andrea M. Collins,

Victoria Connor,

Caz Hales,

Helen Hill,

Angela Hyder-Wright,

Seher Zaidi,

Esther L. German,

Jenna F. Gritzfeld,

Elena Mitsi,

Sherin Pojar,

Stephen B. Gordon,

Adam P. Roberts,

Jamie Rylance,

Daniela M. Ferreira

Publication year - 2019

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jiz034

Subject(s) - colonization , serotype , medicine , streptococcus pneumoniae , antibiotics , pneumococcal conjugate vaccine , microbiology and biotechnology , virology , biology

Pneumococcal colonization is rarely studied in adults, except as part of family surveys. We report the outcomes of colonization screening in healthy adults (all were nonsmokers without major comorbidities or contact with children aged <5 years) who had volunteered to take part in clinical research. Using nasal wash culture, we detected colonization in 6.5% of volunteers (52 of 795). Serotype 3 was the commonest serotype (10 of 52 isolates). The majority of the remaining serotypes (35 of 52 isolates) were nonvaccine serotypes, but we also identified persistent circulation of serotypes 19A and 19F. Resistance to at least 1 of 6 antibiotics tested was found in 8 of 52 isolates.

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