Immunization of Malaria-Preexposed Volunteers With PfSPZ Vaccine Elicits Long-Lived IgM Invasion-Inhibitory and Complement-Fixing Antibodies | Zendy

Isabelle Zenklusen | Zendy; Said Jongo | Zendy; Salim Abdulla | Zendy; Kamaka Ramadhani | Zendy; B. Kim Lee Sim | Zendy; Hayley Cardamone | Zendy; Erika L. Flannery | Zendy; Thao Nguyen | Zendy; Matthew Fishbaugher | Zendy; Ryan W. J. Steel | Zendy; Will Betz | Zendy; Nelly Carmago | Zendy; Sebastian A. Mikolajczak | Zendy; Stefan H. I. Kappe | Zendy; Stephen L. Hoffman | Zendy; Brandon K. Sack | Zendy; Claudia Daubenberger | Zendy

Open Access

Immunization of Malaria-Preexposed Volunteers With PfSPZ Vaccine Elicits Long-Lived IgM Invasion-Inhibitory and Complement-Fixing Antibodies

Author(s) -

Isabelle Zenklusen,

Said Jongo,

Salim Abdulla,

Kamaka Ramadhani,

B. Kim Lee Sim,

Hayley Cardamone,

Erika L. Flannery,

Thao Nguyen,

Matthew Fishbaugher,

Ryan W. J. Steel,

Will Betz,

Nelly Carmago,

Sebastian A. Mikolajczak,

Stefan H. I. Kappe,

Stephen L. Hoffman,

Brandon K. Sack,

Claudia Daubenberger

Publication year - 2018

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jiy080

Subject(s) - plasmodium falciparum , circumsporozoite protein , antibody , virology , immunization , complement fixation test , malaria vaccine , immunology , biology , immunoglobulin g , malaria , serology

The assessment of antibody responses after immunization with radiation-attenuated, aseptic, purified, cryopreserved Plasmodium falciparum sporozoites (Sanaria PfSPZ Vaccine) has focused on IgG isotype antibodies. Here, we aimed to investigate if P. falciparum sporozoite binding and invasion-inhibitory IgM antibodies are induced following immunization of malaria-preexposed volunteers with PfSPZ Vaccine.

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