Open AccessQuantifying the Impact of Natural Immunity on Rotavirus Vaccine Efficacy Estimates: A Clinical Trial in Dhaka, Bangladesh (PROVIDE) and a Simulation Study
Author(s) -
Elizabeth T. Rogawski McQuade,
James A Platts-Mills,
E. Ross Colgate,
Rashidul Haque,
Khalequz Zaman,
William A. Petri,
Beth D. Kirkpatrick
Publication year - 2017
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jix668
Subject(s) - vaccine efficacy , rotavirus , medicine , incidence (geometry) , rotavirus vaccine , diarrhea , clinical trial , confidence interval , immunity , vaccination , herd immunity , vaccine trial , immunology , virology , immune system , physics , optics
The low efficacy of rotavirus vaccines in clinical trials performed in low-resource settings may be partially explained by acquired immunity from natural exposure, especially in settings with high disease incidence.
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