DC-SIGN Polymorphisms Associate with Risk of Hepatitis C Virus Infection Among Men who Have Sex with Men but not Among Injecting Drug Users | Zendy

Gaby S. Steba | Zendy; Sylvie M. Koekkoek | Zendy; Joost W. Vanhommerig | Zendy; Kees Brinkman | Zendy; David Kwa | Zendy; Jan T. M. van der Meer | Zendy; Maria Prins | Zendy; Ben Berkhout | Zendy; Michael W.T. Tanck | Zendy; William A. Paxton | Zendy; Richard Molenkamp | Zendy; Janke Schinkel | Zendy

Open Access

DC-SIGN Polymorphisms Associate with Risk of Hepatitis C Virus Infection Among Men who Have Sex with Men but not Among Injecting Drug Users

Author(s) -

Gaby S. Steba,

Sylvie M. Koekkoek,

Joost W. Vanhommerig,

Kees Brinkman,

David Kwa,

Jan T. M. van der Meer,

Maria Prins,

Ben Berkhout,

Michael W.T. Tanck,

William A. Paxton,

Richard Molenkamp,

Janke Schinkel

Publication year - 2017

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jix587

Subject(s) - single nucleotide polymorphism , dc sign , hepatitis c virus , men who have sex with men , cohort , virus , virology , immunology , biology , hepatitis c , medicine , genotype , genetics , gene , human immunodeficiency virus (hiv) , dendritic cell , immune system , syphilis

We aimed to identify whether genetic polymorphisms within L-SIGN or DC-SIGN correlate with hepatitis C virus (HCV) susceptibility. A men who have sex with men (MSM) and an injecting drug users (IDU) cohort of HCV cases and multiple-exposed uninfected controls were genotyped for numerous L-SIGN and DC-SIGN polymorphisms. DC-SIGN single nucleotide polymorphisms (SNPs) -139, -871, and -939 correlated with HCV acquisition in the MSM cohort only. When the same SNPs were introduced into a transcription activity assay they demonstrated a reduction in expression with predicted alteration in binding of transcription factors. DC-SIGN promoter SNPs correlated with risk of HCV acquisition via sexual but not IDU exposure, likely through modulation of mRNA expression levels.

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