Zika Virus Replicates in Proliferating Cells in Explants From First-Trimester Human Placentas, Potential Sites for Dissemination of Infection | Zendy

Takako Tabata | Zendy; Matthew Petitt | Zendy; Henry PuertaGuardo | Zendy; Daniela Michlmayr | Zendy; Eva Harris | Zendy; Lenore Pereira | Zendy

Open Access

Zika Virus Replicates in Proliferating Cells in Explants From First-Trimester Human Placentas, Potential Sites for Dissemination of Infection

Author(s) -

Takako Tabata,

Matthew Petitt,

Henry PuertaGuardo,

Daniela Michlmayr,

Eva Harris,

Lenore Pereira

Publication year - 2017

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jix552

Subject(s) - biology , decidua , zika virus , virology , cytotrophoblast , chorionic villi , placenta , immunology , andrology , fetus , virus , pregnancy , medicine , genetics

Maternal Zika virus (ZIKV) infection with prolonged viremia leads to fetal infection and congenital Zika syndrome. Previously, we reported that ZIKV infects primary cells from human placentas and fetal membranes. Here, we studied viral replication in numerous explants of anchoring villi and basal decidua from first-trimester human placentas and midgestation amniotic epithelial cells (AmEpCs).

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