Whole-Genome Next-Generation Sequencing to Study Within-Host Evolution of Norovirus (NoV) Among Immunocompromised Patients With Chronic NoV Infection | Zendy

Janko van Beek | Zendy; Miranda de Graaf | Zendy; Saskia L. Smits | Zendy; Claudia M. E. Schapendonk | Zendy; Georges M. G. M. Verjans | Zendy; Harry Vennema | Zendy; Annemiek A. van der Eijk | Zendy; My V. T. Phan | Zendy; Matthew Cotten | Zendy; Marion Koopmans | Zendy

Open Access

Whole-Genome Next-Generation Sequencing to Study Within-Host Evolution of Norovirus (NoV) Among Immunocompromised Patients With Chronic NoV Infection

Author(s) -

Janko van Beek,

Miranda de Graaf,

Saskia L. Smits,

Claudia M. E. Schapendonk,

Georges M. G. M. Verjans,

Harry Vennema,

Annemiek A. van der Eijk,

My V. T. Phan,

Matthew Cotten,

Marion Koopmans

Publication year - 2017

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jix520

Subject(s) - norovirus , biology , population , virology , genome , viral evolution , phylogenetic tree , virus , capsid , host (biology) , rna , genetic diversity , genetics , gene , medicine , environmental health

The genus Norovirus comprises large genetic diversity, and new GII.4 variants emerge every 2-3 years. It is unknown in which host these new variants originate. Here we study whether prolonged shedders within the immunocompromised population could be a reservoir for newly emerging strains.

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