Open AccessThe Impact of Human Papillomavirus Catch-Up Vaccination in Australia: Implications for Introduction of Multiple Age Cohort Vaccination and Postvaccination Data Interpretation
Author(s) -
Mélanie Drolet,
Jean-François Laprise,
Julia Brotherton,
Basil Donovan,
Christopher K. Fairley,
Hammad Ali,
Élodie Bénard,
Dave Martin,
Marc Brisson
Publication year - 2017
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jix476
Subject(s) - vaccination , medicine , cervical cancer , human papillomavirus , demography , cohort , herd immunity , transmission (telecommunications) , environmental health , herd , immunology , cancer , veterinary medicine , computer science , telecommunications , sociology
We used transmission-dynamic modeling to estimate the added effectiveness of vaccinating multiple cohorts of females (12-26 years) in Australia compared with the theoretical introduction of routine-only (12-13 years) vaccination. Our results suggest that vaccinating multiple cohorts produced markedly faster direct/herd effects, and it added benefits that last for 20-70 years. Furthermore, the number needed to vaccinate to prevent 1 anogential warts (AGW) case or cervical cancer (CC) was similar for routine + catch-up (AGW = 9.9, CC = 678) and routine-only vaccination (AGW = 9.9, CC = 677), thus providing similar levels of efficiency per person vaccinated.
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