Associations of Plasma Cytokine and Microbial Translocation Biomarkers With Immune Reconstitution Inflammatory Syndrome | Zendy

Varghese George | Zendy; Linda Harrison | Zendy; Margaret Roach | Zendy; Xiaodong Li | Zendy; Camlin Tierney | Zendy; Margaret A. Fischl | Zendy; Judith A. Aberg | Zendy; Pablo Tebas | Zendy; David M. Asmuth | Zendy; Richard B. Pollard | Zendy; Catherine Godfrey | Zendy; Savita Pahwa | Zendy

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Associations of Plasma Cytokine and Microbial Translocation Biomarkers With Immune Reconstitution Inflammatory Syndrome

Author(s) -

Varghese George,

Linda Harrison,

Margaret Roach,

Xiaodong Li,

Camlin Tierney,

Margaret A. Fischl,

Judith A. Aberg,

Pablo Tebas,

David M. Asmuth,

Richard B. Pollard,

Catherine Godfrey,

Savita Pahwa

Publication year - 2017

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jix460

Subject(s) - immune reconstitution inflammatory syndrome , immunology , inflammation , cd14 , immune system , medicine , chromosomal translocation , cxcl10 , biomarker , systemic inflammation , pathogenesis , biology , chemokine , virus , viral load , antiretroviral therapy , gene , biochemistry

A nested case-cohort study was performed in participants of a clinical trial of first-line human immunodeficiency virus treatments to investigate plasma biomarkers of inflammation and microbial translocation for their association with immune reconstitution inflammatory syndrome (IRIS). Fifty-one of 1452 participants with baseline CD4 count <350 cells/μL developed IRIS. Plasma from 51 IRIS cases, including 6 stratified by preenrollment CD4 count ≤200 cells/μL, were analyzed and compared to 94 non-IRIS controls. At baseline, CXCL10, lipopolysaccharide, soluble CD14, 16S ribosomal DNA, and interferon-α2 were associated with greater risk of IRIS. Systemic inflammation through persistent monocyte activation and microbial translocation appear to be important in IRIS pathogenesis.

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