An Iron-Rich Diet Decreases the Mycobacterial Burden and Correlates With Hepcidin Upregulation, Lower Levels of Proinflammatory Mediators, and Increased T-Cell Recruitment in a Model of Mycobacterium bovis Bacille Calmette-Guerin Infection | Zendy

Rafiou Agoro | Zendy; Sulayman Benmerzoug | Zendy; Stéphanie Rose | Zendy; Mélanie Bouyer | Zendy; Raffaella Gozzelino | Zendy; Irene García | Zendy; Bernhard Ryffel | Zendy; Valérie Quesniaux | Zendy; Catherine Mura | Zendy

Open Access

An Iron-Rich Diet Decreases the Mycobacterial Burden and Correlates With Hepcidin Upregulation, Lower Levels of Proinflammatory Mediators, and Increased T-Cell Recruitment in a Model of Mycobacterium bovis Bacille Calmette-Guerin Infection

Author(s) -

Rafiou Agoro,

Sulayman Benmerzoug,

Stéphanie Rose,

Mélanie Bouyer,

Raffaella Gozzelino,

Irene García,

Bernhard Ryffel,

Valérie Quesniaux,

Catherine Mura

Publication year - 2017

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jix366

Subject(s) - proinflammatory cytokine , inflammation , ferroportin , immunology , mycobacterium bovis , hepcidin , biology , immune system , iron deficiency , microbiology and biotechnology , cytokine , downregulation and upregulation , mycobacterium tuberculosis , medicine , tuberculosis , anemia , gene , biochemistry , pathology

Recent evidence indicates a robust competition between the host and mycobacteria for iron acquisition during mycobacterial infection. Variable effects of iron supplementation on the susceptibility to mycobacterial infection have been reported. In this study, we revisited the effects of an experimental iron-enriched diet on Mycobacterium bovis bacille Calmette-Guerin (BCG) infection.

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