Open AccessContinued Transmission of Zika Virus in Humans in West Africa, 1992–2016
Author(s) -
Bobby Brooke Herrera,
Charlotte A. Chang,
Donald J. Hamel,
Souleymane Mboup,
Daouda Ndiaye,
Godwin Imade,
Jonathan Okpokwu,
Oche Agbaji,
Amy K. Bei,
Phyllis J. Kanki
Publication year - 2017
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jix182
Subject(s) - zika virus , seroprevalence , virology , outbreak , dengue fever , dengue virus , transmission (telecommunications) , flavivirus , aedes , biology , geography , virus , antibody , immunology , serology , electrical engineering , engineering
First identified in 1947 in Uganda, Zika virus (ZIKV) has remained largely unstudied until the recent outbreak in Latin America. This study aimed to measure the prevalence of ZIKV in febrile patients in Senegal and Nigeria in samples collected from 1992 to 2016. The seroprevalence of ZIKV was 6.2% based on ZIKV immunoglobulin M and negative for dengue reactivity. ZIKV envelope was amplified from 4 samples. Phylogenetic analysis showed that the ZIKVs belonged to the African lineage, grouping with either the Nigerian or MR766 sublineages. This study provides evidence that ZIKV has been silently circulating in West Africa for 2 decades.
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