Open AccessViral Pathogen Detection by Metagenomics and Pan-Viral Group Polymerase Chain Reaction in Children With Pneumonia Lacking Identifiable Etiology
Author(s) -
Robert Schlaberg,
Krista Queen,
Keith E. Simmon,
Keith D. Tardif,
Chris Stockmann,
Steven Flygare,
Brett Kennedy,
Karl V. Voelkerding,
Anna M. Bramley,
Jing Zhang,
Karen Eilbeck,
Mark Yandell,
Seema Jain,
Andrew T. Pavia,
Suxiang Tong,
Krow Ampofo
Publication year - 2017
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jix148
Subject(s) - metagenomics , polymerase chain reaction , pneumonia , virology , pathogen , etiology , biology , viral pneumonia , microbiology and biotechnology , medicine , gene , covid-19 , genetics , pathology , infectious disease (medical specialty) , disease
Community-acquired pneumonia (CAP) is a leading cause of pediatric hospitalization. Pathogen identification fails in approximately 20% of children but is critical for optimal treatment and prevention of hospital-acquired infections. We used two broad-spectrum detection strategies to identify pathogens in test-negative children with CAP and asymptomatic controls.
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