Open AccessSecretor and Salivary ABO Blood Group Antigen Status Predict Rotavirus Vaccine Take in Infants
Author(s) -
Abdul Momin Kazi,
Margaret M. Cortese,
Ying Yu,
Benjamin A. Lopman,
Ardythe L. Morrow,
Jessica A. Fleming,
Monica McNeal,
A. Duncan Steele,
Umesh D. Parashar,
Anita K. M. Zaidi,
Asad Ali
Publication year - 2017
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jix028
Subject(s) - abo blood group system , rotavirus , saliva , seroconversion , antigen , virology , antibody , biology , immunology , group a , reoviridae , rotavirus vaccine , medicine , virus
Histo-blood group antigens (HBGAs) expressed on enterocytes are proposed receptors for rotaviruses and can be measured in saliva. Among 181 Pakistani infants in a G1P[8] rotavirus vaccine trial who were seronegative at baseline, anti-rotavirus immunoglobulin A seroconversion rates after 3 vaccine doses differed significantly by salivary HBGA phenotype, with the lowest rate (19%) among infants who were nonsecretors (ie, who did not express the carbohydrate synthesized by FUT2), an intermediate rate (30%) among secretors with non-blood group O, and the highest rate (51%) among secretors with O blood group. Differences in HBGA expression may be responsible for some of the discrepancy in the level of protection detected for the current rotavirus vaccines in low-income versus high-income settings.
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