Open AccessThe Matrine Derivate MASM Prolongs Survival, Attenuates Inflammation, and Reduces Organ Injury in Murine Established Lethal Sepsis
Author(s) -
Jing Xu,
Keqi Wang,
WeiHeng Xu,
Yinghua Li,
Qi Yang,
Hongyuan Wu,
Jianzhong Li,
Zhi-gao He,
Honggang Hu,
Yan Wang,
Junping Zhang
Publication year - 2016
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiw445
Subject(s) - sepsis , lipopolysaccharide , tumor necrosis factor alpha , pharmacology , in vitro , inflammation , cytokine , biology , immunology , chemistry , medicine , biochemistry
MASM, a novel derivative of matrine, has inhibitory effects on activation of macrophages, dendritic cells, and hepatic stellate cells and binds to ribosomal protein S5 (RPS5). This study was designed to evaluate the effect of MASM on murine-established lethal sepsis and its mechanisms.
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