Vaccine-Induced Immunogenicity and Protection AgainstPneumocystisPneumonia in a Nonhuman Primate Model of HIV andPneumocystisCoinfection | Zendy

Heather M. Kling | Zendy; Karen A. Norris | Zendy

Open Access

Vaccine-Induced Immunogenicity and Protection AgainstPneumocystisPneumonia in a Nonhuman Primate Model of HIV andPneumocystisCoinfection

Author(s) -

Heather M. Kling,

Karen A. Norris

Publication year - 2016

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jiw032

Subject(s) - pneumocystis jirovecii , immunogenicity , virology , pneumocystis carinii , pneumonia , immunology , coinfection , pneumocystis pneumonia , biology , medical microbiology , immune system , virus , medicine , human immunodeficiency virus (hiv)

The ubiquitous opportunistic pathogen Pneumocystis jirovecii causes pneumonia in immunocompromised individuals, including human immunodeficiency virus (HIV)-infected individuals, and pulmonary colonization with P. jirovecii is believed to be a cofactor in the development of chronic obstructive pulmonary disease. There is no vaccine for P. jirovecii; however, most adults are seropositive, indicating natural immune priming to this pathogen. We have shown that humoral response to a recombinant subunit of the P. jirovecii protease kexin (KEX1) correlates with protection from P. jirovecii colonization and pneumonia.

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