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Oral vaccination with live-attenuated Salmonella Typhi strain Ty21a is modestly efficacious, but the mechanisms of protection are currently unknown. While humoral and cellular immune responses are well described in peripheral blood, the cellular response at the intestinal mucosa has never been directly assessed.

the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases

Oral Typhoid Vaccination With Live-AttenuatedSalmonellaTyphi Strain Ty21a Generates Ty21a-Responsive and Heterologous Influenza Virus–Responsive CD4+and CD8+T Cells at the Human Intestinal Mucosa