Open AccessOral Typhoid Vaccination With Live-AttenuatedSalmonellaTyphi Strain Ty21a Generates Ty21a-Responsive and Heterologous Influenza Virus–Responsive CD4+and CD8+T Cells at the Human Intestinal Mucosa
Author(s) -
Shaun H. Pennington,
Ameeka Thompson,
Adam Wright,
Daniela M. Ferreira,
Kondwani Jambo,
Angela D. Wright,
Brian Faragher,
Jill Gilmour,
Stephen B. Gordon,
Melita A. Gordon
Publication year - 2016
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiw030
Subject(s) - salmonella typhi , virology , typhoid fever , vaccination , immune system , attenuated vaccine , microbiology and biotechnology , cellular immunity , immunology , biology , typhoid vaccine , salmonella , cd8 , bacteria , escherichia coli , virulence , gene , biochemistry , genetics
Oral vaccination with live-attenuated Salmonella Typhi strain Ty21a is modestly efficacious, but the mechanisms of protection are currently unknown. While humoral and cellular immune responses are well described in peripheral blood, the cellular response at the intestinal mucosa has never been directly assessed.
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