Whole-Exome Sequencing Reveals Mutations in Genes Linked to Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome in Fatal Cases of H1N1 Influenza | Zendy

Grant S. Schulert | Zendy; Mingce Zhang | Zendy; Ndate Fall | Zendy; Ammar Husami | Zendy; Diane Kissell | Zendy; Andrew Hanosh | Zendy; Kejian Zhang | Zendy; Kristina A. Davis | Zendy; Jeffrey M. Jentzen | Zendy; Lena M. Napolitano | Zendy; Javed Siddiqui | Zendy; Lauren B. Smith | Zendy; Paul W. Harms | Zendy; Alexei A. Grom | Zendy; Randy Q. Cron | Zendy

Open Access

Whole-Exome Sequencing Reveals Mutations in Genes Linked to Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome in Fatal Cases of H1N1 Influenza

Author(s) -

Grant S. Schulert,

Mingce Zhang,

Ndate Fall,

Ammar Husami,

Diane Kissell,

Andrew Hanosh,

Kejian Zhang,

Kristina A. Davis,

Jeffrey M. Jentzen,

Lena M. Napolitano,

Javed Siddiqui,

Lauren B. Smith,

Paul W. Harms,

Alexei A. Grom,

Randy Q. Cron

Publication year - 2015

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jiv550

Subject(s) - hemophagocytic lymphohistiocytosis , exome sequencing , macrophage activation syndrome , hemophagocytosis , immunology , biology , perforin , mutation , gene , cytolysis , virology , genetics , medicine , disease , immune system , cytotoxic t cell , cd8 , pathology , bone marrow , arthritis , pancytopenia , in vitro

Severe H1N1 influenza can be lethal in otherwise healthy individuals and can have features of reactive hemophagocytic lymphohistiocytosis (HLH). HLH is associated with mutations in lymphocyte cytolytic pathway genes, which have not been previously explored in H1N1 influenza.

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