Open AccessCharacterization of a Bivalent Vaccine Capable of Inducing Protection Against Both Ebola and Cross-clade H5N1 Influenza in Mice
Author(s) -
Gary Wong,
Xiangguo Qiu,
Hideki Ebihara,
Heinz Feldmann,
Gary P. Kobinger
Publication year - 2015
Publication title -
the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiv257
Subject(s) - virology , influenza a virus subtype h5n1 , biology , hemagglutinin (influenza) , immune system , microbiology and biotechnology , virus , bivalent (engine) , vesicular stomatitis , heterologous , vesicular stomatitis virus , immunology , gene , genetics , chemistry , organic chemistry , metal
Ebola virus (EBOV) is a lethal pathogen that causes up to 90% mortality in humans, whereas H5N1 avian influenza has a 60% fatality rate. Both viruses are considered pandemic threats. The objective was to evaluate the protective efficacy of a bivalent, recombinant vesicular stomatitis virus vaccine expressing both the A/Hanoi/30408/2005 H5N1 hemagglutinin and the EBOV glycoprotein (VSVΔG-HA-ZGP) in a lethal mouse model of infection.