Open AccessThe Role of Conserved N-Linked Glycans on Ebola Virus Glycoprotein 2
Author(s) -
Nicholas J. Lennemann,
Madeline Walkner,
Abigail R. Berkebile,
Neil Patel,
Wendy Maury
Publication year - 2015
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiv201
Subject(s) - ebola virus , glycoprotein , glycan , virology , ebolavirus , biology , membrane glycoproteins , virus , genetics
N-linked glycosylation is a common posttranslational modification found on viral glycoproteins (GPs) and involved in promoting expression, cellular attachment, protection from proteases, and antibody evasion. The GP subunit GP2 of filoviruses contains 2 completely conserved N-linked glycosylation sites (NGSs) at N563 and N618, suggesting that they have been maintained through selective pressures.
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