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Some Streptococcus pneumoniae serotypes express an ahemolytic pneumolysin (PLYa). Serotypes that commonly express PLYa, including serotype 8 (ST8) and ST1, are often associated with a low prevalence during colonization but a higher propensity to cause invasive disease. We sought to study the host response to ST8 PLYa in a homologous and heterologous capsular background.

the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases

An Ahemolytic Pneumolysin of<i>Streptococcus Pneumoniae</i>Manipulates Human Innate and CD4<sup>+</sup>T-Cell Responses and Reduces Resistance to Colonization in Mice in a Serotype-Independent Manner

An Ahemolytic Pneumolysin ofStreptococcus PneumoniaeManipulates Human Innate and CD4+T-Cell Responses and Reduces Resistance to Colonization in Mice in a Serotype-Independent Manner

An Ahemolytic Pneumolysin ofStreptococcus PneumoniaeManipulates Human Innate and CD4⁺T-Cell Responses and Reduces Resistance to Colonization in Mice in a Serotype-Independent Manner