Open AccessAn Ahemolytic Pneumolysin ofStreptococcus PneumoniaeManipulates Human Innate and CD4+T-Cell Responses and Reduces Resistance to Colonization in Mice in a Serotype-Independent Manner
Author(s) -
M. Nadeem Khan,
J. Robert Coleman,
Joshua Vernatter,
Avanish K. Varshney,
Chad Dufaud,
Liise-anne Pirofski
Publication year - 2014
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiu321
Subject(s) - pneumolysin , streptococcus pneumoniae , serotype , microbiology and biotechnology , colonization , biology , heterologous , pneumococcal infections , virology , antibiotics , gene , genetics
Some Streptococcus pneumoniae serotypes express an ahemolytic pneumolysin (PLYa). Serotypes that commonly express PLYa, including serotype 8 (ST8) and ST1, are often associated with a low prevalence during colonization but a higher propensity to cause invasive disease. We sought to study the host response to ST8 PLYa in a homologous and heterologous capsular background.
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