Methylprednisolone Enhances the Growth of Exserohilum rostratum In Vitro, Attenuates Spontaneous Apoptosis, and Increases Mortality Rates in Immunocompetent Drosophila Flies | Zendy

Dimitrios Farmakiotis | Zendy; Fazal Shirazi | Zendy; Yanan Zhao | Zendy; Peguy J. Saad | Zendy; Nathaniel D. Albert | Zendy; Emmanuel Roilides | Zendy; Thomas J. Walsh | Zendy; David S. Perlin | Zendy; Dimitrios P. Kontoyiannis | Zendy

Open Access

Methylprednisolone Enhances the Growth of Exserohilum rostratum In Vitro, Attenuates Spontaneous Apoptosis, and Increases Mortality Rates in Immunocompetent Drosophila Flies

Author(s) -

Dimitrios Farmakiotis,

Fazal Shirazi,

Yanan Zhao,

Peguy J. Saad,

Nathaniel D. Albert,

Emmanuel Roilides,

Thomas J. Walsh,

David S. Perlin,

Dimitrios P. Kontoyiannis

Publication year - 2014

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jiu289

Subject(s) - exserohilum , methylprednisolone , in vitro , conidium , virulence , biology , microbiology and biotechnology , apoptosis , mycelium , veterinary medicine , medicine , botany , gene , genetics , blight

High concentrations of methylprednisolone (0.32 mg/mL) accelerated growth and attenuated spontaneous apoptosis of Exserohilum rostratum in vitro. Injection of E. rostratum conidia preexposed to 0.32 mg/mL of methylprednisolone for 7 days in immunocompetent flies led to increased mortality and a higher fungal burden. Exposure to methylprednisolone could enhance the virulence of E. rostratum.

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