Open AccessInteraction of Drug- and Granulocyte-Mediated Killing of Pseudomonas aeruginosa in a Murine Pneumonia Model
Author(s) -
George L. Drusano,
Weiguo Liu,
Steven Fikes,
Ryan T. Cirz,
Nichole Robbins,
Stephanie Kurhanewicz,
Jaime L. Rodriquez,
David Brown,
Dodge L. Baluya,
Arnold Louie
Publication year - 2014
Publication title -
the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiu237
Subject(s) - pseudomonas aeruginosa , aminoglycoside , bacterial pneumonia , microbiology and biotechnology , pneumonia , antibiotics , medicine , antimicrobial , granulocyte , bacteria , immunology , pharmacology , biology , genetics
Killing of bacterial pathogens by granulocytes is a saturable process, as previously demonstrated. There is virtually no quantitative information about how granulocytes interact with antimicrobial chemotherapy to kill bacterial cells.