Open AccessDifferent Effects of Whole-Cell and Acellular Vaccines on Bordetella Transmission
Author(s) -
William E. Smallridge,
Olivier Rolin,
Nathan T. Jacobs,
Eric T. Harvill
Publication year - 2014
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiu030
Subject(s) - transmission (telecommunications) , virology , microbiology and biotechnology , bordetella , bordetella pertussis , biology , medicine , immunology , bacteria , computer science , telecommunications , genetics
Vaccine development has largely focused on the ability of vaccines to reduce disease in individual hosts, with less attention to assessing the vaccine's effects on transmission between hosts. Current acellular vaccines against Bordetella pertussis are effective in preventing severe disease but have little effect on less severe coughing illness that can mediate transmission.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom