Vaccination Against Staphylococcus aureus Pneumonia | Zendy

Adam R. Spaulding | Zendy; Wilmara SalgadoPabón | Zendy; Joseph A. Merriman | Zendy; Christopher S. Stach | Zendy; Yongping Ji | Zendy; Aaron Nicholas Gillman | Zendy; Marnie L. Peterson | Zendy; Patrick M. Schlievert | Zendy

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Vaccination Against Staphylococcus aureus Pneumonia

Author(s) -

Adam R. Spaulding,

Wilmara SalgadoPabón,

Joseph A. Merriman,

Christopher S. Stach,

Yongping Ji,

Aaron Nicholas Gillman,

Marnie L. Peterson,

Patrick M. Schlievert

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit823

Subject(s) - superantigen , staphylococcus aureus , vaccination , pneumonia , medicine , immunology , microbiology and biotechnology , antigen , staphylococcal infections , virology , biology , immune system , bacteria , t cell , genetics

Staphylococcus aureus causes serious infections in both hospital and community settings. Attempts have been made to prevent human infection through vaccination against bacterial cell-surface antigens; thus far all have failed. Here we show that superantigens and cytolysins, when used in vaccine cocktails, provide protection from S. aureus USA100-USA400 intrapulmonary challenge.

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