Serum Antibody Response to Matrix Protein 2 Following Natural Infection With 2009 Pandemic Influenza A(H1N1) Virus in Humans | Zendy

Weimin Zhong | Zendy; Carrie Reed | Zendy; Patrick J. Blair | Zendy; Jacqueline M. Katz | Zendy; Kathy Hancock | Zendy; Darbi Aranio | Zendy; Yaohui Bai | Zendy; Peter Browning | Zendy; Alicia Branch | Zendy; Evelene StewardClark | Zendy; Li Cronin | Zendy; Hanan Dababneh | Zendy; Eric P. Gillis | Zendy; Crystal Holiday | Zendy; Feng Liu | Zendy; Xiuhua Lu | Zendy; Heather Tatum | Zendy; Conrad P. Quinn | Zendy; Stephen Soroka | Zendy; Jarad Schiffer | Zendy; Hong Sun | Zendy; Leilani Thomas | Zendy; Byron Tsang | Zendy; Vic Veguilla | Zendy; David Wang | Zendy; Melissa Whaley | Zendy

Open Access

Serum Antibody Response to Matrix Protein 2 Following Natural Infection With 2009 Pandemic Influenza A(H1N1) Virus in Humans

Author(s) -

Weimin Zhong,

Carrie Reed,

Patrick J. Blair,

Jacqueline M. Katz,

Kathy Hancock,

Darbi Aranio,

Yaohui Bai,

Peter Browning,

Alicia Branch,

Evelene StewardClark,

Li Cronin,

Hanan Dababneh,

Eric P. Gillis,

Crystal Holiday,

Feng Liu,

Xiuhua Lu,

Heather Tatum,

Conrad P. Quinn,

Stephen Soroka,

Jarad Schiffer,

Hong Sun,

Leilani Thomas,

Byron Tsang,

Vic Veguilla,

David Wang,

Melissa Whaley

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit811

Subject(s) - antibody , virus , virology , influenza a virus , immunology , biology , seroprevalence , humoral immunity , antibody response , pandemic , viral matrix protein , serology , medicine , disease , covid-19 , infectious disease (medical specialty)

Natural infection-induced humoral immunity to matrix protein 2 (M2) of influenza A viruses in humans is not fully understood. Evidence suggests that anti-M2 antibody responses following influenza A virus infection are weak and/or transient. We show that the seroprevalence of anti-M2 antibodies increased with age in 317 serum samples from healthy individuals in the United States in 2007-2008. Infection with 2009 pandemic H1N1 influenza A virus (A[H1N1]pdm09) elicited a recall serum antibody response to M2 protein of A(H1N1)pdm09 in 47% of the affected 118 individuals tested. Anti-M2 antibody responses were more robust among individuals with preexisting antibodies to M2 protein. Moreover, the antibodies induced as a result of infection with A(H1N1)pdm09 were cross-reactive with M2 protein of seasonal influenza A viruses. These results emphasize the need to further investigate the possible roles of anti-M2 antibodies in human influenza A virus infection.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research