Monocyte Activation by Interferon α Is Associated With Failure to Achieve a Sustained Virologic Response After Treatment for Hepatitis C Virus Infection | Zendy

Dennis J. Hartigan-O’Connor | Zendy; Din L. Lin | Zendy; James C. Ryan | Zendy; Valentina Shvachko | Zendy; Myrna Cozen | Zendy; Mark R. Segal | Zendy; Norah A. Terrault | Zendy; Lewis L. Lanier | Zendy; M. Michele Manos | Zendy; Joseph M. McCune | Zendy

Open Access

Monocyte Activation by Interferon α Is Associated With Failure to Achieve a Sustained Virologic Response After Treatment for Hepatitis C Virus Infection

Author(s) -

Dennis J. Hartigan-O’Connor,

Din L. Lin,

James C. Ryan,

Valentina Shvachko,

Myrna Cozen,

Mark R. Segal,

Norah A. Terrault,

Lewis L. Lanier,

M. Michele Manos,

Joseph M. McCune

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit801

Subject(s) - ribavirin , immunology , hepatitis c virus , medicine , interferon , monocyte , hepacivirus , alpha interferon , virus , viral load , pegylated interferon , hepatitis c , virology

Interferon α (IFN-α) and ribavirin can induce a sustained virologic response (SVR) in some but not all hepatitis C virus (HCV)-infected patients. The mechanism of effective treatment is unclear. One possibility is that IFN-α differentially improves the functional capacity of classic myeloid dendritic cells (mDCs) by altering expression of surface molecules or cytokines. Others have proposed that antigen-presenting cell activation could be paradoxically detrimental during HCV infection because of the production by monocytes of substances inhibitory or toxic to plasmacytoid dendritic cells.

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