Correlate of Immune Protection Against HSV-1 Genital Disease in Vaccinated Women | Zendy

Robert B. Belshe | Zendy; Thomas C. Heineman | Zendy; David I. Bernstein | Zendy; Abbie R. Bellamy | Zendy; Marian Ewell | Zendy; Robbert van der Most | Zendy; Carolyn Deal | Zendy

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Correlate of Immune Protection Against HSV-1 Genital Disease in Vaccinated Women

Author(s) -

Robert B. Belshe,

Thomas C. Heineman,

David I. Bernstein,

Abbie R. Bellamy,

Marian Ewell,

Robbert van der Most,

Carolyn Deal

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit651

Subject(s) - immunology , immune system , medicine , antibody , vaccine efficacy , vaccination , vaccine trial , hsl and hsv , disease , sex organ , virology , biology , virus , genetics

Previously we conducted a double-blind controlled, randomized efficacy field trial of gD-2 HSV vaccine adjuvanted with ASO4 in 8323 women. Subjects had been previously selected to be seronegative for HSV-1 and HSV-2. We found that vaccine was 82% protective against HSV-1 genital disease, but offered no significant protection against HSV-2 genital disease.

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