Amelioration of Cryptosporidium parvum Infection In Vitro and In Vivo by Targeting Parasite Fatty Acyl-Coenzyme A Synthetases | Zendy

Fengguang Guo | Zendy; Han Zhang | Zendy; Jason M. Fritzler | Zendy; S. Dean Rider | Zendy; Lixin Xiang | Zendy; Nina McNair | Zendy; Jan R. Mead | Zendy; Guan Zhu | Zendy

Open Access

Amelioration of Cryptosporidium parvum Infection In Vitro and In Vivo by Targeting Parasite Fatty Acyl-Coenzyme A Synthetases

Author(s) -

Fengguang Guo,

Han Zhang,

Jason M. Fritzler,

S. Dean Rider,

Lixin Xiang,

Nina McNair,

Jan R. Mead,

Guan Zhu

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit645

Subject(s) - cryptosporidium parvum , biology , microbiology and biotechnology , in vitro , in vivo , parasite hosting , cryptosporidium , recombinant dna , biochemistry , virology , feces , gene , world wide web , computer science

Cryptosporidium is emerging as 1 of the 4 leading diarrheal pathogens in children in developing countries. Its infections in patients with AIDS can be fatal, whereas fully effective treatments are unavailable. The major goal of this study is to explore parasite fatty acyl-coenzyme A synthetase (ACS) as a novel drug target.

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