Incident Herpes Simplex Virus Type 2 Infection Increases the Risk of Subsequent Episodes of Bacterial Vaginosis | Zendy

Linnet N. Masese | Zendy; Jared M. Baeten | Zendy; Barbara A. Richardson | Zendy; E. Bukusi | Zendy; Grace JohnStewart | Zendy; Walter Jaoko | Zendy; J. Shafi | Zendy; James Kiarie | Zendy; R. Scott McClelland | Zendy

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Incident Herpes Simplex Virus Type 2 Infection Increases the Risk of Subsequent Episodes of Bacterial Vaginosis

Author(s) -

Linnet N. Masese,

Jared M. Baeten,

Barbara A. Richardson,

E. Bukusi,

Grace JohnStewart,

Walter Jaoko,

J. Shafi,

James Kiarie,

R. Scott McClelland

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit634

Subject(s) - bacterial vaginosis , herpes simplex virus , herpes genitalis , immunology , medicine , virus , herpesviridae , virology , viral disease , genital herpes , obstetrics

Herpes simplex virus type 2 (HSV-2) infected women have a higher prevalence of bacterial vaginosis (BV) compared to HSV-2-seronegative women. To explore the temporal association between these conditions, we evaluated the frequency of BV episodes before and after HSV-2 acquisition in a prospective study of 406 HSV-2/HIV-1-seronegative Kenyan women, of whom 164 acquired HSV-2. Incident HSV-2 was associated with increased likelihood of BV (adjusted OR, 1.28; 95% CI, 1.05-1.56; P = .01). Our findings strengthen the evidence for a causal link between genital HSV-2 infection and disruption of the vaginal microbiota.

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