Cycline Efficacy on the Propagation of Human Prions in Primary Cultured Neurons is Strain-Specific | Zendy

Samia Hannaoui | Zendy; Alexianne Gougerot | Zendy; Nicolas Privat | Zendy; Etienne Levavasseur | Zendy; Nicolas Bizat | Zendy; JeanJacques Hauw | Zendy; JeanPhilippe Brandel | Zendy; Stéphane Haı̈k | Zendy

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Cycline Efficacy on the Propagation of Human Prions in Primary Cultured Neurons is Strain-Specific

Author(s) -

Samia Hannaoui,

Alexianne Gougerot,

Nicolas Privat,

Etienne Levavasseur,

Nicolas Bizat,

JeanJacques Hauw,

JeanPhilippe Brandel,

Stéphane Haı̈k

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit623

Subject(s) - doxycycline , scrapie , virology , biology , strain (injury) , disease , prion protein , in vitro , microbiology and biotechnology , antibiotics , medicine , pathology , genetics , anatomy

In prion diseases, a major issue in therapeutic research is the variability of the effect between strains. Stimulated by the report of an antiprion effect in a scrapie model and by ongoing international clinical trials using doxycycline, we studied the efficacy of cyclines against the propagation of human prions. First, we successfully propagated various Creutzfeldt-Jakob disease (CJD) isolates (sporadic, variant, and iatrogenic CJD) in neuronal cultures expressing the human prion protein. Then, we found that doxycycline was the most effective compound, with important variations between isolates. Isolates from sporadic CJD, the most common form of prion disease, showed the highest sensitivity.

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