L-Type Bovine Spongiform Encephalopathy in Genetically Susceptible and Resistant Sheep: Changes in Prion Strain or Phenotypic Plasticity of the Disease-Associated Prion Protein? | Zendy

Simon Nicot | Zendy; Anna Bencsik | Zendy; Sergio Migliore | Zendy; Dominique Canal | Zendy; Mikael Leboidre | Zendy; Umberto Agrimi | Zendy; Romolo no | Zendy; Thierry Baron | Zendy

Open Access

L-Type Bovine Spongiform Encephalopathy in Genetically Susceptible and Resistant Sheep: Changes in Prion Strain or Phenotypic Plasticity of the Disease-Associated Prion Protein?

Author(s) -

Simon Nicot,

Anna Bencsik,

Sergio Migliore,

Dominique Canal,

Mikael Leboidre,

Umberto Agrimi,

Romolo no,

Thierry Baron

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit596

Subject(s) - bovine spongiform encephalopathy , biology , phenotype , prion protein , virology , strain (injury) , gene , genetics , disease , pathology , medicine , anatomy

Sheep with prion protein (PrP) gene polymorphisms QQ171 and RQ171 were shown to be susceptible to the prion causing L-type bovine spongiform encephalopathy (L-BSE), although RQ171 sheep specifically propagated a distinctive prion molecular phenotype in their brains, characterized by a high molecular mass protease-resistant PrP fragment (HMM PrPres), distinct from L-BSE in QQ171 sheep.

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