Open AccessAn Animal Model of MERS Produced by Infection of Rhesus Macaques With MERS Coronavirus
Author(s) -
Yufeng Yao,
Linlin Bao,
Wei Deng,
Lili Xu,
Fang Li,
Qi Lv,
Pin Yü,
Ting Chen,
Yiyao Xu,
Hua Zhu,
Jing Yuan,
Songzhi Gu,
Wei Qin,
Honglin Chen,
KwokYung Yuen,
Chuan Qin
Publication year - 2013
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jit590
Subject(s) - middle east respiratory syndrome coronavirus , virology , middle east respiratory syndrome , coronavirus , biology , immunology , disease , medicine , covid-19 , infectious disease (medical specialty) , pathology
In 2012, a novel coronavirus (CoV) associated with severe respiratory disease, Middle East respiratory syndrome (MERS-CoV; previously known as human coronavirus-Erasmus Medical Center or hCoV-EMC), emerged in the Arabian Peninsula. To date, 114 human cases of MERS-CoV have been reported, with 54 fatalities. Animal models for MERS-CoV infection of humans are needed to elucidate MERS pathogenesis and to develop vaccines and antivirals. In this study, we developed rhesus macaques as a model for MERS-CoV using intratracheal inoculation. The infected monkeys showed clinical signs of disease, virus replication, histological lesions, and neutralizing antibody production, indicating that this monkey model is suitable for studies of MERS-CoV infection.
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