Evidence for Innate Immune System Activation in HIV Type 1–Infected Elite Controllers | Zendy

Sonya Krishnan | Zendy; Eleanor Wilson | Zendy; Virginia Sheikh | Zendy; Adam Rupert | Zendy; Daniel Mendoza | Zendy; Jun Yang | Zendy; Richard A. Lempicki | Zendy; Stephen A. Migueles | Zendy; Irini Sereti | Zendy

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Evidence for Innate Immune System Activation in HIV Type 1–Infected Elite Controllers

Author(s) -

Sonya Krishnan,

Eleanor Wilson,

Virginia Sheikh,

Adam Rupert,

Daniel Mendoza,

Jun Yang,

Richard A. Lempicki,

Stephen A. Migueles,

Irini Sereti

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit581

Subject(s) - innate immune system , elite , human immunodeficiency virus (hiv) , immune system , immunology , biology , neuroscience , virology , computer science , political science , politics , law

Elite controllers maintain high CD4(+) T-cell counts and suppress plasma human immunodeficiency virus (HIV) viremia in the absence of antiretroviral therapy (ART). It is unclear whether levels of biomarkers associated with coagulation, monocyte activation, and inflammation, which are linked to HIV-associated mortality, differ among elite controllers, ART recipients with suppressed viremia (plasma HIV type 1 RNA load, <50 copies/mL), and HIV-negative controls.

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