Open AccessTransplacental Transfer of Azithromycin and Its Use for Eradicating Intra-amniotic Ureaplasma Infection in a Primate Model
Author(s) -
Edward P. Acosta,
Peta L. Grigsby,
Kajal Larson,
Annie James,
Mary C. Long,
Lynn B. Duffy,
Ken B. Waites,
Miles J. Novy
Publication year - 2013
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jit578
Subject(s) - amniotic fluid , ureaplasma , pharmacokinetics , azithromycin , medicine , transplacental , fetus , andrology , regimen , pregnancy , ureaplasma urealyticum , biology , placenta , mycoplasma , microbiology and biotechnology , antibiotics , genetics
Our goals were to describe azithromycin (AZI) pharmacokinetics in maternal plasma (MP), fetal plasma (FP), and amniotic fluid (AF) following intra-amniotic infection (IAI) with Ureaplasma in pregnant rhesus monkeys and to explore concentration-response relationships.
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