A Novel Cytomegalovirus-Induced Regulatory-Type T-Cell Subset Increases in Size During Older Life and Links Virus-Specific Immunity to Vascular Pathology
Author(s) -
Nadia Terrazzini,
Martha Bajwa,
Serena Vita,
Elizabeth Cheek,
David W. Thomas,
Nabila Seddiki,
Helen Smith,
Florian Kern
Publication year - 2013
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jit576
Subject(s) - cytomegalovirus , immunity , immunology , virus , cellular immunity , biology , cytomegalovirus infection , human cytomegalovirus , endothelium , vascular smooth muscle , betaherpesvirinae , pathology , immune system , virology , medicine , herpesviridae , viral disease , smooth muscle , endocrinology
Cytomegalovirus (CMV) infection directly targets vascular endothelium and smooth muscle and at older ages is associated with accelerated vascular pathology and mortality. CMV-specific cellular immunity might directly contribute to this process.
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