CCR5 Expression Is Reduced in Lymph Nodes of HIV Type 1-Infected Women, Compared With Men, But Does Not Mediate Sex-Based Differences in Viral Loads
Author(s) -
Amie L. Meditz,
Joy M. Folkvord,
Ngan H. Lyle,
Kristina Searls,
Yolanda Lie,
Eoin Coakley,
Martin D. McCarter,
Samantha MaWhinney,
Elizabeth Connick
Publication year - 2013
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jit575
Subject(s) - viral load , lymph node , lentivirus , lymph , viral replication , rna , virus , immunology , biology , flow cytometry , virology , viral disease , medicine , pathology , gene , genetics
Human immunodeficiency virus type 1 (HIV-1)-infected women have lower viral loads than men but similar rates of disease progression. We hypothesized that sex-based differences in CCR5 expression mediate viral load differences.
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