Functional Polymorphisms in the Gene Encoding Macrophage Migration Inhibitory Factor Are Associated With Gram-Negative Bacteremia in Older Adults | Zendy

Rituparna Das | Zendy; Lakshman Subrahmanyan | Zendy; Ivana V. Yang | Zendy; David van Duin | Zendy; Rebecca Levy | Zendy; Marta Piecychna | Zendy; Lin Leng | Zendy; Ruth R. Montgomery | Zendy; Albert C. Shaw | Zendy; David A. Schwartz | Zendy; Richard Bucala | Zendy

Open Access

Functional Polymorphisms in the Gene Encoding Macrophage Migration Inhibitory Factor Are Associated With Gram-Negative Bacteremia in Older Adults

Author(s) -

Rituparna Das,

Lakshman Subrahmanyan,

Ivana V. Yang,

David van Duin,

Rebecca Levy,

Marta Piecychna,

Lin Leng,

Ruth R. Montgomery,

Albert C. Shaw,

David A. Schwartz,

Richard Bucala

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit571

Subject(s) - macrophage migration inhibitory factor , immunology , bacteremia , lipopolysaccharide , genotype , monocyte , locus (genetics) , biology , medicine , gene , cytokine , microbiology and biotechnology , genetics , antibiotics

Macrophage migration inhibitory factor (MIF) is an immune mediator encoded in a functionally polymorphic locus. We found the genotype conferring low expression of MIF to be enriched in a cohort of 180 patients with gram-negative bacteremia, compared with 229 healthy controls (odds ratio [OR], 2.4; P = .04), an association that was more pronounced in older adults (OR, 4.6; P = .01). Among older subjects, those with low expression of MIF demonstrated 20% reduced MIF production from lipopolysaccharide-stimulated peripheral blood monocytes and 30% lower monocyte surface Toll-like receptor 4, compared with those with high expression. Our work suggests that older adults with low expression of MIF may be predisposed to hyporesponsiveness to lipopolysaccharide and gram-negative bacterial infection.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research