Naturally Acquired Antibodies Specific for Plasmodium falciparum Reticulocyte-Binding Protein Homologue 5 Inhibit Parasite Growth and Predict Protection From Malaria | Zendy

Tuan M. Tran | Zendy; Aissata Ongoïba | Zendy; Jill D. Coursen | Zendy; Cécile Crosnier | Zendy; Ababacar Diouf | Zendy; ChiungYu Huang | Zendy; Shanping Li | Zendy; Safiatou Doumbo | Zendy; Didier Doumtabé | Zendy; Younoussou Koné | Zendy; Aboudramane Bathily | Zendy; Seydou Dia | Zendy; Moussa Niangaly | Zendy; Charles Dara | Zendy; Jules Sangala | Zendy; Louis H. Miller | Zendy; Ogobara K. Doumbo | Zendy; Kassoum Kayentao | Zendy; Carole A. Long | Zendy; Kazutoyo Miura | Zendy; Gavin J. Wright | Zendy; Boubacar Traoré | Zendy; Peter D. Crompton | Zendy

Open Access

Naturally Acquired Antibodies Specific for Plasmodium falciparum Reticulocyte-Binding Protein Homologue 5 Inhibit Parasite Growth and Predict Protection From Malaria

Author(s) -

Tuan M. Tran,

Aissata Ongoïba,

Jill D. Coursen,

Cécile Crosnier,

Ababacar Diouf,

ChiungYu Huang,

Shanping Li,

Safiatou Doumbo,

Didier Doumtabé,

Younoussou Koné,

Aboudramane Bathily,

Seydou Dia,

Moussa Niangaly,

Charles Dara,

Jules Sangala,

Louis H. Miller,

Ogobara K. Doumbo,

Kassoum Kayentao,

Carole A. Long,

Kazutoyo Miura,

Gavin J. Wright,

Boubacar Traoré,

Peter D. Crompton

Publication year - 2013

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jit553

Subject(s) - plasmodium falciparum , reticulocyte , basigin , parasite hosting , biology , antibody , malaria , virology , plasmodium (life cycle) , in vitro , immunology , microbiology and biotechnology , biochemistry , messenger rna , world wide web , computer science , matrix metalloproteinase , gene

Plasmodium falciparum reticulocyte-binding protein homologue 5 (PfRH5) is a blood-stage parasite protein essential for host erythrocyte invasion. PfRH5-specific antibodies raised in animals inhibit parasite growth in vitro, but the relevance of naturally acquired PfRH5-specific antibodies in humans is unclear.

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